Better to Return Whence We Came

Coregulators: from whence came these "master genes".

It is now over a decade since the first nuclear receptor coactivator, SRC-1, was cloned and discovered to be a new type of transcription factor that does not bind DNA, but rather, binds directly or indirectly to nuclear receptors (NRs) to mediate their transcriptional potency. The NR coactivators belong to a class of molecules now termed ‘coregulators’. Employing an ‘operational’ definition, we...

The Theory of Multiple Expansion of Deposits: What It Is and Whence It Came

Beginning students of banking must grapple with a curious paradox: the banking system can multiply deposits on a given base of reserves yet none of its member banks can do so. Let the reserve-to-deposit ratio be, say, 20 percent and the system can, by making loans, create $5 of deposit money per dollar of reserves received. By contrast, the individual bank receiving that same dollar on deposit ...

Pediatric liver failure: we came, we saw, but have we conquered?

Although there have been advances made in the diagnosis and management of pediatric acute liver failure, there is still no consensus regarding the definition or standardized evaluation, and an inability to predict outcomes, specifically irreversible brain injury, in many patients exists. Much of the research surrounding pediatric acute liver failure in the last several years has centered on the...

Osler came to Boston.

The Norwegian National IT Plan, 1987-1990: Whence It Came, What It Was, and How It Ended

In the late 1970s and early 1980s most of the technically advanced nations organized national R&D programs for speeding up the intake of information technologies in industry and society as a whole. In addition, Norway organized a National IT plan that ran for four years from 1987–90. The idea of having a national plan was initiated in 1982–83. This paper shortly covers events of around ten year...